Polynucleotide-Based Skin Therapies: Benefits and Considerations

Polynucleotides (PN) are naturally occurring molecules composed of DNA and RNA fragments. In skincare, they are derived from salmon DNA and work by stimulating tissue regeneration, cell repair, and collagen production.

Unlike surface-level serums, PN-based injectables like Rejuran Healer deliver therapeutic results deep within the skin, helping to repair damage at the cellular level and promote long-term rejuvenation.

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💡 Key Benefits of PN-Based Skin Treatments

Polynucleotide therapy has rapidly become a favorite among dermatologists and aesthetic clinics due to its biocompatibility, efficacy, and anti-inflammatory benefits. Top reasons to choose PN-based treatments include:

  • Boosts collagen and elastin production

  • Repairs damaged skin and enhances wound healing

  • Improves hydration and strengthens the skin barrier

  • Reduces fine lines, texture issues, and enlarged pores

  • ✅ Suitable for sensitive or post-procedure skin

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👤 Who Should Consider Polynucleotide Therapy?

PN-based treatments are ideal for:

  • Individuals with aging or thinning skin

  • Patients recovering from laser or microneedling

  • Those struggling with acne scars or rough texture

  • People seeking glass-skin level smoothness and glow

The treatment is gentle, making it suitable even for sensitive skin types.


🔬 Rejuran vs. Other Polynucleotide Products

Wondering which PN-based solution is right for you? Here's a breakdown:

Product Core Ingredient Best For
Rejuran Healer PDRN (salmon DNA) Anti-aging, barrier repair, elasticity
Curenex PN + Peptides + GF Brightening, texture, and glow
Exosome + PN Cell-signaling combo Advanced rejuvenation and healing

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⚠️ Risks and Considerations

Polynucleotide treatments are safe and well-tolerated, but as with any injectable, it's important to:

  • ✅ Use KFDA- and CE-certified products

  • ✅ Ensure treatment is administered by a trained professional

  • ✅ Expect minor redness or swelling that subsides within 24–48 hours

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💬 Frequently Asked Questions (FAQ)

What is polynucleotide (PN) skin therapy?

It’s a regenerative skin treatment that uses DNA fragments (often from salmon) to stimulate tissue repair and collagen growth.

What are the benefits of Rejuran Healer?

Rejuran helps restore skin elasticity, reduce fine lines, shrink pores, and repair damaged skin—all while calming inflammation.

Is PN better than PRP (platelet-rich plasma)?

PN offers more consistent results and doesn’t rely on individual blood quality. It’s preferred for its anti-inflammatory properties and less downtime.